Here it is, the final issue of 2015, issue #24 of this year, and issue #228 in the Medical Examiner’s long history. The next edition, Issue #229, will be dated January 8, 2016. This may be our best issue yet, beginning with the One-Two punch on page 1: constipation and our can’t fail holiday diet. Does it get any better than that? Well, if you like excruciating pain it does. If that’s you, turn to urologist Darren Mack MD’s page 10 article on how to avoid kidney stones, and do the opposite of everything he recommends. Then keep your fingers crossed. Also in this issue: a brief profile of the physician who saved more lives than any other doctor in the history of medicine. There are highlights on every page, so we’ll get out of the way and let you start clicking.